Clinical Trial: Immunopathology of Autoimmune Hemolytic Anemia
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: Immunopathology of Autoimmune Hemolytic Anemia. Open, Prospective, Multicentre Study.
Brief Summary:
The aim of this study is to compare different blood cells of the immune response in patients with Autoimmune Hemolytic Anemia and healthy subjects.
Evaluate the impact of treatments, notably corticoids, on blood cells of the immune response.
Better understanding of the mechanisms involved in the course of this disease could lead to new treatments.
12 patients with Autoimmune Hemolytic Anemia will be compared with 12 controls matched for sex and age.
Controls will provide blood samples only once. The will have no particular follow-up.
Patients will provide blood samples at the time of diagnosis then 3 months after the start of treatment. If a new treatment needs to be started before the end of the 3-month period, a new blood sample will be taken.
Detailed Summary:
Sponsor: Centre Hospitalier Universitaire Dijon
Current Primary Outcome:
- Blood level and the percentage of Treg (CD4 + CD25HighFoxp3 +) [ Time Frame: Change from baselines blood level and the percentage of Treg at 3 months treatment with corticoids ]
- Percentage of inhibition of proliferation of Treg [ Time Frame: Change from baselines percentage of inhibition of proliferation of Treg at 3 months treatment with corticoids ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Centre Hospitalier Universitaire Dijon
Dates:
Date Received: March 5, 2014
Date Started: July 2013
Date Completion:
Last Updated: June 5, 2014
Last Verified: March 2013
