Clinical Trial: Efficacy of Cognitive Training in Subjective Memory Impairment

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: One Center, Randomized Trial to Assess Efficacy of Cognitive Training in Subjective Memory Impairment

Brief Summary: This study evaluates the efficacy of cognitive training in subjects with subjective memory impairment. The first group will receive cognitive training and lifestyle modification in combination, the second group will receive only lifestyle modification, and the third group will receive no intervention.

Detailed Summary: Subjective memory impairment is currently thought to be a risky state of progression to Alzheimer's disease. This study aims to confirm whether cognitive training in subjective memory impairment would show improvement in the subjective and objective cognition. We include subjects with normal cognition but complained subjective feeling of memory decline and conduct cognitive training programs combined with lifestyle modifications for 3 months. We evaluate the neuropsychological tests and questionnaires about subjective improvement after 3 months of interventions.
Sponsor: Asan Medical Center

Current Primary Outcome:

• Paired associates learning test [ Time Frame: 3 month ]
  paired associates learning test is a part of computerized neuropsychological tests battery named CANTAB (Cambridge Neuropsychological Test Automated Battery). The scores are shown as total number of errors.
• Rapid visual information processing test [ Time Frame: 3 month ]
  rapid visual information processing is a part of computerized neuropsychological test battery named CANTAB. The score is shown as correct response rate.%
• Pattern recognition memory test [ Time Frame: 3 month ]
  paired associates learning test is a part of computerized neuropsychological tests battery named CANTAB (Cambridge Neuropsychological Test Automated Battery). The score is shown as correct response rate.%
• Spatial working memory test [ Time Frame: 3 month ]
  paired associates learning test is a part of computerized neuropsychological tests battery named CANTAB (Cambridge Neuropsychological Test Automated Battery). The scores are shown as total number of errors.
• logical memory test delayed recall [ Time Frame: 3 month ]
  logical memory test is a part of a neuropsychological test named Wechsler Memory Scale. The score is shown as total correct number (range 0-50)

Original Primary Outcome: Same as current

Current Secondary Outcome:

• cognitive failure questionnaire [ Time Frame: 3 month ]
  questionnaire for measuring self reported cognitive status. score range: 0-100. Higher score means worse cognitive status.
• Mini-mental state examination [ Time Frame: 3 month ]
  mini-mental state examination that examines general cognition. range 0-20. Higher score means better cognition.
• Geriatric depression scale [ Time Frame: 3 month ]
  questionnaire for depression measuring. score range:0-15. lower score means less depression.
• Beck anxiety index [ Time Frame: 3 month ]
  questionnaire for self reporting anxiety measuring. range:0-63. low score means less anxiety.
• Seoul instrumental activities of daily living [ Time Frame: 3 month ]
  scale for measuring activities of daily living limitation. score range 0-45. low score means better ability.
• Rey complex figure copy test [ Time Frame: 3 month ]
  test for visuospatial function. Participants should copy the complex figure. score range: 0-36. Higher score means better visuospatial function.
• Digit symbol test [ Time Frame: 3 month ]
  a test for attention and psychomotor speed. Participants are instructed to write an appropriately matched code for each number. Correct number is counted. score range: 0-76. Higher score means better function.
• Seoul verbal learning test, immediate recall [ Time Frame: 3 month ]
  measuring tool for immediate memory function. Investigators read 12 words to participants. Participants should remember the words. Tests are done 3 times. score range: 0-36. Higher score means better immediate memory function
• Seoul verbal learning test, delayed recall [ Time Frame: 3 month ]
  measuring tool for 20 minutes delayed memory function. After 20 minutes from the immediate recall test, participants should remember the words. score range: 0-12. Higher score means better delayed memory function
• Seoul verbal learning test, delayed recall [ Time Frame: 3 month ]
  measuring tool for cued recall of verbal memory function. score range: 0-24. 2. Higher score means better memory recognition function

Original Secondary Outcome: Same as current

Information By: Asan Medical Center

Dates:
Date Received: September 18, 2015
Date Started: May 2014
Date Completion:
Last Updated: July 15, 2016
Last Verified: July 2016