Clinical Trial: Apoptotic Signaling Pathways in Rats With Endometrial Hyperplasia
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: The Effect of Metformin and Medroxyprogesterone Acetate on Apoptotic Signaling Pathways in Wistar-Albino Rats With Induced Endometrial Hyperplasia
Brief Summary: The purpose of the study is to determine apoptotic signaling pathways such as Survivin, Bcl-2, Bax, c-Myc and caspase-9 expression levels in rats model with iatrogenic endometrial hyperplasia after metformin and medroxyprogesterone acetate administration.
Detailed Summary:
Sponsor: Kayseri Education and Research Hospital
Current Primary Outcome:
- Survivin Gene Expression Levels in Rat Uterine Tissue [ Time Frame: 4 months ]
- Bcl-2 Gene Expression Levels in Rat Uterine Tissue [ Time Frame: 4 months ]
- Bax Gene Expression Levels in Rat Uterine Tissue [ Time Frame: 4 months ]
- c-Myc Gene Expression Levels in Rat Uterine Tissue [ Time Frame: 4 months ]
- Caspase-9 Expression Levels in Rat Uterine Tissue [ Time Frame: 4 months ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Kayseri Education and Research Hospital
Dates:
Date Received: August 16, 2016
Date Started: October 2014
Date Completion:
Last Updated: August 22, 2016
Last Verified: August 2016
