Clinical Trial: Lung Function and Inflammatory Markers in Cement Dust Exposed Workers: A Cross-shifts Study

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Circulating Inflammatory Markers, Exhaled NO and Lung Function in Cement Production Workers; a Cross-shifts Study

Brief Summary: The aim of the study is to examine possible changes in lung function, nitric oxide levels and systemic inflammatory markers in cement dust exposed workers, during one shift (6-8 hours).

Detailed Summary:

OBJECTIVE:

Cement dust is suspected to be one of the main factors causing increased mortality among workers not only in the cement production industry, but also in the construction industry worldwide. Our aim is to examine possible changes in lung function, nitric oxide levels and systemic inflammatory markers in cement dust exposed workers, during one shift (6-8 hours).

METHODS:

All employees from Norwegian cement plants, are invited to participate. The workers will perform spirometry, single-breath determination of carbon monoxide uptake, blood samples before and after a working shift of 6-8 hours, and again after 24 hours. Information on respiratory symptoms, allergy and former respiratory disease as well as exposure information will be given on a self-reported questionnaire. Changes in lung function indices, nitric oxide levels and serum inflammatory markers will be calculated. Nitric oxide will only be measured in non-smokers. We will compare cement dust exposed workers with low-level or non-exposed workers (controls).


Sponsor: Sykehuset Telemark

Current Primary Outcome: Changes in Lung Function Measurements During One Work Shift (6-8h) [ Time Frame: baseline and 6-8h ]

Changes in lung function measurements during one work shift (6-8h), spirometry and gass diffusion capacity


Original Primary Outcome: Cross shift changes in lung function, nitric oxide levels and systemic inflammation markers in cement dust exposed workers. [ Time Frame: 8 hrs + 24 hrs ]

Current Secondary Outcome:

  • Changes in FeNO Measurements During One Shift (6-8h) [ Time Frame: baseline and 6-8h ]
  • Changes in Serum/Plasma Inflammatory Markers During One Shift (6-8h) [ Time Frame: Baseline and 6-8h ]
  • Changes in FeNO Measurements Between Baseline (0h) and 32 h [ Time Frame: 0-32h ]
  • Changes in Serum/Plasma Inflammatory Markers Between Baseline and 32 h [ Time Frame: 0-32h ]


Original Secondary Outcome:

Information By: Sykehuset Telemark

Dates:
Date Received: July 30, 2008
Date Started: April 2008
Date Completion:
Last Updated: April 13, 2016
Last Verified: April 2016