Clinical Trial: Safety Study of Continuous Positive Airway Pressure Via a Nasal Mask

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effect of Continuous Positive Airway Pressure Ventilation Through Nasal Mask on Upper Airway Patency During Induction of Anesthesia

Brief Summary: Upper airway obstruction (UAO) is common complication during induction of general anesthesia. The mechanism of UAO during anesthesia has not been well understood. Posterior displacement of soft palate are believed to be the primary contributing factors. The mechanism of UAO during anesthesia share many similarities with obstructive sleep apnea (OSA). Since nasal continuous positive airway pressure (nCPAP) can maintain the airway patent in patients with OSA, the investigators hypothesize that nCPAP during induction of anesthesia will reduce the incidence and severity of UAO.

Detailed Summary:
Sponsor: Massachusetts General Hospital

Current Primary Outcome: expired tidal volume [ Time Frame: Average of one minute after anesthesia induction ]

Estimated time from induction of anesthesia (drugs given for anesthesia induction) to apnea is one minute.


Original Primary Outcome: Same as current

Current Secondary Outcome: volume of CO2 [ Time Frame: Average of one minute after anesthesia induction ]

Estimated time from induction of anesthesia (drugs given for anesthesia induction) to apnea is one minute.


Original Secondary Outcome: Same as current

Information By: Massachusetts General Hospital

Dates:
Date Received: January 12, 2012
Date Started: October 2011
Date Completion:
Last Updated: January 15, 2017
Last Verified: January 2017