Clinical Trial: Cortisol Response to Low Dose Cosyntropin Stimulation Test in the Late Afternoon

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional

Official Title: Cortisol Response to Low Dose Cosyntropin Stimulation Test in the Late Afternoon

Brief Summary: Previous study showed that afternoon cosyntropin testing was associated with a sevenfold increased likelihood of failing the 1μg test. However, in that study, investigators used a 20.3 cm plastic tube, which might have led to uncompleted cosyntropin delivery. In ther current study investigators will study afternoon 1μg cosyntropin cortisol stimulation using a short 2.5 cm tube.

Detailed Summary:

In earlier studies investigators claimed that subnormal cortisol response using plastic tubes might result from cosyntropin adherence to the tube and loss of the delivered dosage. It was shown that 21.6-58.6% of ACTH dosage had not been recovered when pushed through 20.3 cm plastic tube, and loss of ACTH may be up to 70% when cosyntropin was delivered through a plastic 30 cm scalp vein set.

Moreover, it was previously shown that afternoon cosyntropin testing was associated with a sevenfold increased likelihood of failing the 1μg test. However, in that study, investigators used a 20.3 cm plastic tube, which might have led to uncompleted cosyntropin delivery. In ther current study investigators will study afternoon 1μg cosyntropin cortisol stimulation using a short 2.5 cm tube.


Sponsor: Bnai Zion Medical Center

Current Primary Outcome: Blood cortisol [ Time Frame: one day ]

Serum cortisol concentrations during intravenous low dose cosyntropin stimulation through short tube.


Original Primary Outcome:

  • Blood cortisol [ Time Frame: one year ]
    Serum cortisol concentrations during intravenous low dose cosyntropin stimulation through short tube.
  • Salivary free cortisol [ Time Frame: one year ]
    Salivary free cortisol concentrations during intravenous low dose cosyntropin stimulation through short tube.


Current Secondary Outcome: Salivary free cortisol [ Time Frame: one day ]

Salivary free cortisol concentrations during intravenous low dose cosyntropin stimulation through short tube.


Original Secondary Outcome:

Information By: Bnai Zion Medical Center

Dates:
Date Received: March 3, 2017
Date Started: March 20, 2017
Date Completion: June 1, 2018
Last Updated: March 18, 2017
Last Verified: March 2017