Clinical Trial: Use of Dexamethasone in Uterine Artery Embolization

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: The Effect of Dexamethasone on Inflammatory Response After Uterine Artery Embolization

Brief Summary: The primary purpose of this study is to investigate the effects of dexamethasone on inflammatory reactions after uterine artery embolization. The secondary purpose of this study it to investigate the effects of dexamethasone on postembolization syndrome (severe pain, nasea and vomiting).

Detailed Summary:
Sponsor: Severance Hospital

Current Primary Outcome: Inflammatory reactions [ Time Frame: 24 hours ]

CRP, WBC, neutrophil (%), cortisol : pre-UAE, post-UAE 12 h, post-UAE-24 h IL-6 : pre-UAE, post-UAE-24 h


Original Primary Outcome: Inflammatory reactions [ Time Frame: 24 hours ]

CRP, WBC, neutrophil (%), prolactin, cortisol : pre-UAE, post-UAE 12 h, post-UAE-24 h IL-6 : pre-UAE, post-UAE-24 h


Current Secondary Outcome:

  • Pain [ Time Frame: 24 hours ]
    Immediately after UAE, post-UAE 1, 2, 4, 6, 8, 12, 24 h
  • Nausea and vomiting [ Time Frame: 24 hours ]
    Immediately after UAE, post-UAE 1, 2, 4, 6, 8, 12, 24 h
  • Sucessful rate at 3 month after UAE [ Time Frame: 3 month ]
    Utrerine volume and complete necrosis incidence


Original Secondary Outcome:

  • Pain [ Time Frame: 24 hours ]
    Immediately after UAE, post-UAE 1, 2, 4, 6, 8, 12, 24 h
  • Nausea and vomiting [ Time Frame: 24 hours ]
    Immediately after UAE, post-UAE 1, 2, 4, 6, 8, 12, 24 h


Information By: Severance Hospital

Dates:
Date Received: February 3, 2014
Date Started: April 2014
Date Completion:
Last Updated: April 15, 2015
Last Verified: April 2015