Clinical Trial: Ketamine and Morphine Versus Morphine Alone for the Treatment of Acute Pain in the Emergency Department
Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional
Official Title: Ketamine and Morphine Versus Morphine Alone for the Treatment of Acute Pain in the Emergency Department
Brief Summary:
Our goal is to study whether giving people low dose ketamine along with morphine when they come to the Emergency Department will help their pain more than giving morphine by itself. There have been many studies showing that low dose ketamine is safe and effective for pain control. Ketamine is frequently used for pain control in ambulances and helicopters transporting injured patients to the hospital and has also been used for pain control in people who have just had surgery. The investigators would like to see if low dose ketamine would be safe and effective for patients with pain in the Emergency Department.
Patients are eligible for the study if they come to the Emergency Department and their treating physician decides to treat them with morphine (with certain exceptions such as pregnant patients and patients with eye injuries). They will be given information about participating in the study and if they agree, they will be given the study drug. The study drug will be either ketamine or salt water (saline). If patients continue to be in pain they will continue to receive doses of morphine just as they would if they were not in the study. If the treating physician feels that morphine alone is not enough, they will be free to choose another pain medication as they would normally.
Detailed Summary:
Sponsor: University of Arizona
Current Primary Outcome: Change in Numeric pain score [ Time Frame: 30 minutes and 1 hour after receiving study drug ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Total amount of morphine and other pain medications administered [ Time Frame: Data collected from the duration of the patient's Emergency Department stay (expected average 5 hours) ]
- Number of participants with adverse events [ Time Frame: Data collected from the duration of the patient's Emergency Department stay (expected average 5 hours) ]
- Adequate pain control at 30 minutes [ Time Frame: 30 minutes after recieving study drug ]binary data on whether patient has achieved adequate subjective pain control
- Adequate Pain control at 1 hour [ Time Frame: 1 hour after receiving study drug ]binary data on whether patient has achieved adequate subjective pain control
Original Secondary Outcome: Same as current
Information By: University of Arizona
Dates:
Date Received: July 8, 2013
Date Started: June 2013
Date Completion: March 2015
Last Updated: July 12, 2013
Last Verified: July 2013
