Clinical Trial: Effect of the Intensity of Continuous Renal Replacement Therapy in Patients With Acute Kidney Injury

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effect of the Intensity of Continuous Renal Replacement Therapy in Patients With Cardiac Surgery Associated Acute Kidney Injury (CRITERIA STUDY)

Brief Summary: The current international Continuous Renal Replacement Therapy (CRRT) replacement fluid doses of 35 ml/kg/h is better, but the result is according to white people, black people . It is Whether the best amount of replacement fluid for Chinese people, it is unclear. Especially,there is little evidence about the optimal dose from randomized trials in Cardiac surgery associated acute kidney injury (CSA-AKI )required CRRT,According to the clinical situation, the design of replacement fluid to 25 ml/kg/h.The observation of two doses 14 days, 28 days, 90 days survival and renal function.

Detailed Summary: Acute kidney injury (AKI) is a major complication in patients with cardiac surgery and is an independent predictor of mortality. However, the optimal intensity of renal replacement therapy for such patients is still controversial. we randomly assigned the patients with Cardiac surgery-associated acute kidney injury (CSA-AKI) to continuous renal replacement therapy with different treatment dose (35ml / kg / h or 25ml/kg／h),The primary study outcome was death from any cause within 14, 28 and 90 days.
Sponsor: Wei Shi

Current Primary Outcome: death from any cause [ Time Frame: 14, 28 ,90 and 365 days after randomization ]

Original Primary Outcome:

Current Secondary Outcome: renal outcome of survivors [ Time Frame: 14, 28 ,90 and 365 days after randomization ]

Original Secondary Outcome:

Information By: Guangdong General Hospital

Dates:
Date Received: March 20, 2012
Date Started: March 2011
Date Completion:
Last Updated: January 17, 2016
Last Verified: January 2016