Clinical Trial: Prevention of Postoperative Acute Kidney Injury

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional

Official Title: Effect of a Kidney Bundle on the Occurence of Postoperative Acute Kidney Injury in Patients at Risk

Brief Summary: Postoperative acute kidney injury (AKI) refers to increased mortality and morbidity in patients after non-cardiac surgery. The Kidney Disease Improving Global Outcomes (KDIGO)-guidelines recommend a bundle of procedures to prevent the occurrence of AKI: A protocol for the improvement of the hemodynamic situation and a standardized proceeding in hemodynamic monitoring, consequent avoidance of nephrotoxic substances, regular measurement of creatinine and urine output, as well as normoglycemia. The primary goal is to determine if the consequent application of the KDIGO-bundle leads to a prevention of the occurrence of AKI in patients at risk after non-cardiac surgery.

Detailed Summary: All patients included in the study will be treated with the KDIGO-bundle (hemodynamic stabilization, avoidance of nephrotoxic substances, normoglycemia and measurement of creatinine in serum and urine output). 12 h, 24h as well as on day 2, 3, 5 and 10 after admission on ICU the occurence of AKI (according to KDIGO) will be assessed.
Sponsor: Wuerzburg University Hospital

Current Primary Outcome: Incidence of postoperative AKI [ Time Frame: until day 5 after surgery ]

AKI according to KDIGO definition


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Intensive care unit mortality [ Time Frame: 28 days and 90 days after surgery ]
  • hospital mortality [ Time Frame: up to 100 days after surgery ]
  • usage of renal replacement therapy (hours) [ Time Frame: up to 30 days after surgery ]
  • length of invasive respirator therapy (hours) [ Time Frame: up to 30 days after surgery ]
  • creatinine in serum [ Time Frame: 12 hours, day 2, 3, 5 and 10 after surgery ]
  • urine output (total ml) [ Time Frame: after 12 hours, on day 2 (in 24hour), 3 (in 24hour), 5 (in 24hour) and 10 (in 24hour) after surgery ]
  • length of hospital stay [ Time Frame: up to 100 days after surgery ]
  • length of ICU stay [ Time Frame: up to 100 days after surgery ]


Original Secondary Outcome: Same as current

Information By: Wuerzburg University Hospital

Dates:
Date Received: September 23, 2015
Date Started: October 2015
Date Completion: October 2017
Last Updated: October 21, 2015
Last Verified: October 2015