Clinical Trial: Acute Kidney Injury Biomarkers: Diagnosis and Application in Pre-operative Period of Liver Transplantation

Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Observational

Official Title: Acute Kidney Injury Biomarkers: Diagnosis and Application in Pre-operative Period of Liver Transplantation

Brief Summary:

Acute kidney injury (AKI), is a common complication of patients undergoing liver transplantation. Timing and definition of AKI, usually based on serum creatinine, have been inaccurate and inconsistent.

We hypothesized that the pattern of novel biomakers elevation could be a prognostic tool to provide information on the risk of progression of AKI, the need for RRT and mortality.


Detailed Summary:
Sponsor: University of Sao Paulo

Current Primary Outcome: Development of Acute Kidney Injury based on novel biomarkers [ Time Frame: within 7 days ]

Compare the timing for diagnosis of AKI comparing novel biomarkers and serum creatinine defined by Kidney Disease Improving Global Outcomes. In addition, we aim to evaluate if the pattern of elevation of the novel biomarkers provide information on progression and severity of AKI.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Short and long term renal outcomes [ Time Frame: 1 year ]
    renal function and need for RRT
  • Association of urine chemistry and microscopy to predict acute kidney injury [ Time Frame: within 7 days of liver transplantation ]
    Association of urine chemistry and microscopy with novel biomarkers to predict AKI diagnosis and progression


Original Secondary Outcome: Same as current

Information By: University of Sao Paulo

Dates:
Date Received: February 7, 2014
Date Started: June 2013
Date Completion: August 2016
Last Updated: May 15, 2016
Last Verified: May 2016