Clinical Trial: Sublingual Versus Vaginal Misoprostol In Medical Treatment of First Trimestric Missed Miscarriage

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Sublingual Versus Vaginal Misoprostol In Medical Treatment of First Trimestric Missed Miscarriage: A Randomized Controlled Trial.

Brief Summary: The aim of this work is to compare the effectiveness of vaginal versus sub-lingual misoprostol for medical treatment of first trimester missed miscarriage.

Detailed Summary: In women with first trimetric-missed miscarriage, sublingual misoprostol may be as vaginal misoprostol in achievement of successful miscarriage so our aim was to compare the effectiveness of vaginal versus sub-lingual misoprostol for medical treatment of first trimester missed miscarriage.
Sponsor: Ain Shams University

Current Primary Outcome: Completeness of abortion: expulsion of Products of conception (POC)x by visual inspection [ Time Frame: 7 days ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Successful medical abortion: cervical os is closed with endometrial thickness of less than 15 mm [ Time Frame: 7 days ]
  • Failure: endometrial thickness of more than 15 mm on day seven (from third dose of misoprostol) or developing of complications before day seven needing early surgical evacuation. [ Time Frame: 7 days ]
  • Bleeding pattern following treatment [ Time Frame: 7 days ]
    This will be assessed by hemoglobin(g/dl) and haematocrit level after the treatment , if the patients required blood transfusion and number of units transfused and number of days of bleeding
  • Pain resulting from the procedure [ Time Frame: 7 days ]
    this will be assessed by the doses of paracetamol given in mg
  • Additional uterotonic used [ Time Frame: 7 days ]
    additional misoprostol doses in mcg


Original Secondary Outcome: Same as current

Information By: Ain Shams University

Dates:
Date Received: January 27, 2016
Date Started: January 2016
Date Completion: March 2017
Last Updated: February 16, 2016
Last Verified: February 2016