Clinical Trial: Repeated Doses of Misoprostol for Medical Treatment of Missed Miscarriage

Study Status: Suspended
Recruit Status: Suspended
Study Type: Interventional

Official Title: Repeated Doses of Misoprostol for Treatment of Missed Abortion

Brief Summary: Missed abortion is a condition where the fetus has perished but the miscarriage is not expelled. Women often present at a routine ultrasound or with a slight brownish discharge. Traditionally this condition has been treated with curettage or vacuum aspiration. Lately, medical treatment has become more common due to less risk of infection and other complications. The routine medical treatment is 800mcg of misoprostol administered vaginally. We wish to examine of repeated doses of 400mcg misoprostol after the initial 800mcg vaginal misoprostol increases efficacy of the treatment.

Detailed Summary:
Sponsor: Kristina Gemzell Danielsson

Current Primary Outcome: Efficacy [ Time Frame: 1 day ]

Complete abortion as judged by ultrasound


Original Primary Outcome: Same as current

Current Secondary Outcome: Acceptability [ Time Frame: 1 day, 1 week, 2 weeks, 3 weeks, 5 weeks ]

questionnaire on future choice of treatment method. Surgical or medical treatment if free choice. If having to have medical would she choose repeated doses or single dose?


Original Secondary Outcome: Acceptability [ Time Frame: 1 day, 1 week, 2 weeks, 3 weeks, 5 weeks ]

as assessed by questionnaire


Information By: Karolinska Institutet

Dates:
Date Received: June 4, 2012
Date Started: May 2012
Date Completion: October 2020
Last Updated: March 2, 2017
Last Verified: March 2017