Clinical Trial: Role of Sildenafil Citrate in Patients With Unexplained Recurrent Miscarriages

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Role of Sildenafil Citrate in Patients With Unexplained Recurrent Miscarriages: a Randomized Clinical Trial

Brief Summary: The purpose of this study is to determine whether sildenafil citrate is effective in improving uterine artery blood flow and oxidative stress in patients with unexplained recurrent miscarriages

Detailed Summary:
Sponsor: Ain Shams University

Current Primary Outcome: Uterine arteries blood flow [ Time Frame: 21 days ]

Uterine arteries blood flow assessed by Doppler U/S by measuring Systolic / diastolic ratio, pulsatility index and resistance index


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Nitric oxide serum level as a marked of oxidative stress [ Time Frame: 21 days ]
  • Total antioxidant capacity serum level as a marker of oxidative stress [ Time Frame: 21 days ]


Original Secondary Outcome: Same as current

Information By: Ain Shams University

Dates:
Date Received: August 17, 2011
Date Started: September 2011
Date Completion: June 2012
Last Updated: April 14, 2012
Last Verified: April 2012