Clinical Trial: Genetic Abnormalities and Oxidative Stress in Sperm as Cause of Recurrent Miscarriage.

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Genetic Abnormalities and Oxidative Stress in Sperm as Cause of Recurrent Miscarriage.

Brief Summary: In recurrent miscarriage, the male factor has been poorly evaluated. In fact, in the vast majority of clinical protocols of recurrent miscarriage, the sperm is not considered or assessed. Recently, some studies have suggested the presence of genetic and metabolic sperm anomalies in couples suffering from repeated miscarriages. Specifically, DNA fragmentation and altered oxidative stress in the sperm and Y microdeletions from blood samples have been related to an increased risk of miscarriage.The aim of the present study is to compare these three parameters in: couples with recurrent miscarriage; oligozoospermic men with or without recurrent miscarriages; and healthy sperm donors, in order to determine their actual impact on this reproductive problem.

Detailed Summary:
Sponsor: Instituto Valenciano de Infertilidad, IVI VALENCIA

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Information By: Instituto Valenciano de Infertilidad, IVI VALENCIA

Dates:
Date Received: March 13, 2007
Date Started: February 2007
Date Completion:
Last Updated: October 21, 2015
Last Verified: October 2015