Clinical Trial: 4-PBA: Will it Increase the Level of Alpha 1-Antitrypsin(AAT) in Persons With AAT Deficiency?

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: "4 Phenyl Butyrate Mediated Secretion Rescue in Alpha 1-Antitrypsin Deficient Individuals"

Brief Summary: The purpose of this study is to find out whether 4-PBA will increase the level of AAT in persons with AAT deficiency whether or not they have liver disease.

Detailed Summary: The purpose of this study is to determine whether 4-PBA will significantly increase serum Z AAT levels in AAT-deficient individuals with and without evidence of hepatocellular injury and to assess its effects on liver injury.
Sponsor: University of Florida

Current Primary Outcome: To determine if 4-PBA significantly increases secretion of AAT in AAT-deficient individuals with and without liver disease. [ Time Frame: 10 days ]

Original Primary Outcome:

Current Secondary Outcome: To determine the pharmacokinetics of 4-PBA [ Time Frame: 10 days ]

Original Secondary Outcome:

Information By: University of Florida

Dates:
Date Received: August 26, 2003
Date Started: November 2001
Date Completion:
Last Updated: January 2, 2014
Last Verified: April 2013