Clinical Trial: Airflow Perturbation Device (APD) for the Evaluation of Pulmonary and Sleep Disorders

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Airflow Perturbation Device (APD) for the Evaluation of Pulmonary and Sleep Disorders

Brief Summary: In a prospective, observational study the investigators compared resistance values measured using the airway perturbation device (APD) to impulse oscillometry and spirometry. The investigators also created reference equations for normal APD resistance ranges using the data from clinically normal volunteers.

Detailed Summary:
Sponsor: Walter Reed National Military Medical Center

Current Primary Outcome: Number of participants with APD correlation > 0.5 with spirometry [ Time Frame: At enrollment ]

Respiratory resistance ( cm H20/L/s) measured with APD correlated with volumes (in liters) measured by spirometry.


Original Primary Outcome:

  • Respiratory resistance ( cm H20/L/s) measured with APD correlated with volumes (in liters) measured by spirometry [ Time Frame: At enrollment ]
    APD resistance values and volumes measured by spirometry will be obtained from each participant and compared using bivariate correlation coefficients.
  • Respiratory resistance (cm H20/L/s) measured with APD correlated with resistance (cm H20/L/s) measured using impulse oscillometry [ Time Frame: At enrollment ]
    APD respiratory resistance values and respiratory resistance measured by impulse oscillometry will be obtained from each participant and compared using bivariate correlation coefficients.
  • Develop reference equations for normal APD airway resistance (cm H20/L/s) values [ Time Frame: At enrollment ]
    All participants will have respiratory resistance measured by the APD. For those participants free from respiratory disease or symptoms, APD airway resistance values will be used to develop equations (using linear regression) for normal APD resistance ranges.


Current Secondary Outcome: Number of participants with APD correlation > 0.5 with impulse oscillometry [ Time Frame: At enrollment ]

Respiratory resistance (cm H20/L/s) measured with APD correlated with resistance (cm H20/L/s) measured using impulse oscillometry


Original Secondary Outcome:

Information By: Walter Reed National Military Medical Center

Dates:
Date Received: February 8, 2017
Date Started: April 1, 2013
Date Completion:
Last Updated: February 19, 2017
Last Verified: February 2017